Actinomycetota Isolated from the sponge Hymeniacidon perlevis as a Source of Novel Compounds with Pharmacological Applications: Diversity, Bioactivity Screening, and Metabolomic Analysis

Ana C FonsecaInês RibeiroMariana GirãoAna RegueirasRalph Urbatzka Pedro Leão Maria F Carvalho 

Abstract: To combat health conditions, such as multi-resistant bacterial infections, cancer, and metabolic diseases, new drugs need to be urgently found and, in this respect, marine Actinomycetota have a high potential to produce secondary metabolites with pharmacological importance. We aimed to study the cultivable Actinomycetota community associated with a marine sponge from the Portuguese coast, Hymeniacidon perlevis, and investigate the potential of the retrieved isolates to produce compounds with antimicrobial, anticancer and anti-obesity properties.

https://doi.org/10.1093/jambio/lxaf044